The GOAT ANTI MOUSE CD184 (N-TERMINAL) Antibody from MyBioSource.com is a Goat Polyclonal antibody to CD184, CXCR4, PBSF/SDF-1, and WHIM. This antibody recognizes Mouse, and Xenopus/Amphibian antigen. The GOAT ANTI MOUSE CD184 (N-TERMINAL) Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
MBS223913 recognises an epitope within the N-terminal (NT) region of mouse CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1). Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B-lymphopoiesis and myelopoiesis. CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates. MBS223913 is reported as suitable for use in immunocytochemistry on mouse spleen leucocytes